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5–four μmol/L assortment,[156][157] the concentration of serotonin in synaptic vesicles was calculated at 270 mM.[182] next vesicular release, the resulting concentration of serotonin from the synaptic cleft, to which serotonin receptors are uncovered, is estimated to be about 300 μmol/L. Hence, although in vitro receptor binding affinities,
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